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维生素D缺乏及身体虚弱间的关系:一项全面综述及荟萃分析

Association of vitamin D deficiency and frailty: A systematic review and meta-analysis

来源:Scopus 发布时间:2016-11-23
作者:Zhou, J., Huang, P., Liu, P., Hao, Q., Chen, S., Dong, B. , Wang, J.
机构: 四川大学华西医院老年学及老年医学中心
期刊: MATURITAS2016年11月期94卷

There is a biologically plausible association between low vitamin D, specifically serum 25-hydroxyvitamin D [25(OH)D] level, and frailty. We conducted a systematic review and meta-analysis to describe the association between low 25(OH)D level and frailty. We searched literature in OVID (Medline), EMBASE, Web of Knowledge and Cochrane CENTRAL Library Issue in May 2016, for cohort studies evaluating association of low 25(OH)D level with the risk of frailty. Studies were reviewed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA) guidelines. A total of seven studies(17,815 participants)were eligible in our study. The prevalence of frailty ranged from 3.9% to 31.9%. The pooled OR of frailty for the lowest versus the highest level of vitamin D was 1.27 (95% CI = 1.17–1.38, I2 = 59%), suggesting that low level of vitamin D was significantly associated with the risk of frailty. In addition, results of subgroups analysis indicated that low level of vitamin D was significantly associated with the risk of frailty in female (pooled OR = 1.27, 95% CI = 1.15–1.40). Similar result was also found when frailty was defined by the Fried criteria or the modified Fried criteria (pooled OR = 1.25, 95% CI = 1.14–1.37), and FRAIL scale (pooled OR = 1.55, 95% CI = 1.07–2.25). Compared to the highest level of 25(OH)D, the association between frailty and the lowest level of 25(OH)D was significant in our study.

© 2016

通讯作者:The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China
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