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早期补救性卵胞浆内单精子显微注射后的新生儿预后:一项五年时期的分析

Neonatal outcomes after early rescue intracytoplasmic sperm injection: An analysis of a 5-year period

来源:Scopus 发布时间:2015-8-7
作者:Huang, B., Qian, K., Li, Z., Yue, J., Yang, W., Zhu, G., Zhang, H.
机构: 华中科技大学同济医院 生殖医学中心
期刊: FERTIL STERIL2015年6月6期103卷

Objective To evaluate the safety and efficacy of early rescue intracytoplasmic sperm injection (ICSI). Design Retrospective cohort study. Setting Teaching hospital. Patient(s) There were 13,232 ovarian stimulation cycles (IVF, n = 9,631; ICSI, n = 2,871; early rescue ICSI, n = 730) that resulted in the delivery of 5,001 babies (IVF, n = 3,670; ICSI, n = 1,095; early rescue ICSI, n = 246) from August 2008 to August 2013. Intervention(s) Early rescue ICSI. Main Outcome Measure(s) Clinical pregnancy rates, neonatal outcomes, and congenital birth defects were analyzed. Result(s) The early rescue ICSI cycles did not seem to have a negative effect on the clinical pregnancy rate (43.42%) when IVF cycles (45.33%) were compared with ICSI cycles (44.39%). In the early rescue ICSI group, a total of 254 clinical pregnancies were achieved: 197 (33.67%) live births, 38 (6.49%) miscarriages, 2 (0.79%) induced abortions, 3 (1.18%) fetal deaths, and 4 pregnancies (1.57%) without completion at follow-up. Overall, the multiple gestations, the delivery method, mean gestational age, preterm deliveries, mean birth weight, and rate of congenital birth defects of the early rescue ICSI group were similar to those in the conventional IVF and ICSI groups. Conclusion(s) Early rescue ICSI had similar clinical pregnancy rates when compared with conventional IVF and ICSI, in addition to the delivery of healthy children. The clinical evidence from the early rescue ICSI group did not show an elevated rate of malformations. Early rescue ICSI seems to be a safe alternative method for individuals with total fertilization failure or near total fertilization failure when compared with conventional IVF treatment. © 2015 American Society for Reproductive Medicine.

 

 

通讯作者:Reproductive Medicine Center, Tongji Hospital, Huazhong University of Science and Technology, 1095 JieFang Avenue, Wuhan, China
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