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接受腹股沟管下曲张精索静脉切除术显微手术的中国男性的自然受孕率以及影响此结局的可能术前因素

Spontaneous pregnancy rates in Chinese men undergoing microsurgical subinguinal varicocelectomy and possible preoperative factors affecting the outcomes

来源:Scopus 发布时间:2015-8-6
作者:Peng, J., Zhang, Z. , Cui, W., Yuan, Y., Song, W., Gao, B., Xin, Z., Zhu, S.
机构: 北京大学第一医院男科中心
期刊: FERTIL STERIL2015年3月3期103卷

Objective To investigate pregnancy rates after microsurgical varicocelectomy in Chinese infertile men with clinical varicoceles and to identify preoperative factors affecting the outcomes. Design Retrospective data analysis. Setting University infertility clinic. Patient(s) One hundred seventy-six consecutive Chinese men with infertility and clinical varicoceles who underwent varicocelectomy from January 2010 to December 2011. Semen data were available for 145 patients, and pregnancy data were available for 66. Intervention(s) Varicocelectomy was performed on all patients. Main Outcome Measure(s) Spontaneous pregnancy rates and improvement in semen parameters after varicocelectomy. Result(s) We followed 145 men (82.4%) for a median of 21 months (range 12-36 months) after varicocelectomy. For 109 patients (75.2%), both sperm concentration and forward motility improved. Overall, 45.5% (66/145) of female partners achieved spontaneous pregnancy at a mean follow-up of 11.7 ± 6.2 months. On univariate analysis, preoperative high sperm concentration (≥20 million/mL) and high sperm motility (≥25%) were positively associated with spontaneous pregnancy. On multivariate analysis, only preoperative sperm concentration was an independent predictor. Conclusion(s) Microsurgical varicocelectomy could improve semen quality and spontaneous pregnancy rates. Only preoperative sperm concentration was an independent predictor of spontaneous pregnancy. Patients with high initial sperm concentration may benefit from varicocelectomy for spontaneous pregnancy. © 2015 American Society for Reproductive Medicine.

 

通讯作者:Andrology Center, Peking University First Hospital, #8 Xishiku Street, Beijing, China
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