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母亲在妊娠期间的咖啡摄入量与儿童期急性白血病

Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: A metaanalysis

来源:Scopus 发布时间:2014-7-1
作者:Cheng, J., Su, H. , Zhu, R., Wang, X., Peng, M., Song, J., Fan, D.
机构: 安徽医科大学公共卫生学院流行病与卫生统计学系
期刊: AM J OBSTET GYNECOL2014年2月2期210卷

Abstract

OBJECTIVE:

This study was undertaken to explore the association between maternal coffee consumption during pregnancy and childhood acuteleukemia (AL).

STUDY DESIGN:

The PubMed database was used to search studies up to May 5, 2013, and the lists of references of retrieved articles were also screened to identify additional relevant studies. Studies were included if they reported the odds ratio and corresponding 95% confidence interval (CI) ofchildhood AL, including childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), with respect to maternal coffeeconsumption during pregnancy.

RESULTS:

Compared with non/lowest drinkers, the combined odds ratio regarding the relationship of maternal coffee consumption during pregnancyand childhood AL was 1.22 (95% CI, 1.04-1.43) for ever drinkers, 1.16 (95% CI, 1.00-1.34) for low to moderate-level drinkers, and 1.72 (95% CI, 1.37-2.16) for high-level drinkers. When analysis was conducted by subtypes of childhood AL, maternal coffee consumption (high-level drinkers vs non/lowest drinkers) was statistically significantly associated with childhood ALL (1.65; 95% CI, 1.28-2.12) and childhood AML (1.58; 95% CI, 1.20-2.08). We observed the linear dose-response relationship of coffee consumption and childhood AL (P for nonlinearity = .68), including childhood ALL and childhood AML; with increased coffee consumption, the risk of childhood AL increased.

CONCLUSION:

The findings of the metaanalysis suggest that maternal coffee consumption during pregnancy may increase the risk of childhood AL. Because of limited studies, further prospective studies are urgently needed to explore the adverse effect of coffee consumption on childhood AL.

Copyright © 2014 Mosby, Inc. All rights reserved.

KEYWORDS:

childhood leukemiacoffee consumptionmetaanalysis

通讯作者:Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, 81 Meishan Rd., Hefei, Anhui Province 230032, China
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